NACSELD 3

Determine the prognosis of outpatients with compensated and decompensated cirrhosis followed prospectively.

Focus: Hospitalizations and ACLF development, Clinical Predictors of 1-year and 5-year outcomes, & translational analysis.

Steering Committee

Jasmohan S Bajaj, MD

Virginia Commonwealth University , Richmond, VA
K Rajender Reddy, MD

University of Pennsylvania, Philadelphia, PA
Jacqueline G O’leary, MD

Dallas VA Medical Center Dallas, TX
Florence Wong, MD

University of Toronto, Toronto, Canada
Patrick S Kamath

Mayo Clinic, Rochester, MN

Participating Sites & PIs

Yale University, New Haven, CT

Guadalupe Garcia-Tsao, MD
University of Alberta, Edmonton, Canada

Puneeta Tandon, MD
University of Washington, Seattle, WA

Scott W Biggins, MD and Philip Vutien, MD
University of California, San Francisco, CA

Jennifer C Lai, MD
Mayo Clinic, Phoenix, AZ

Hugo E Vargas, MD

Data & Biorepository

VCU Data Coordinating Center, Richmond, VA
Statisticians: Scott Silvey PhD, Leroy R Thacker PhD
Data Management: Brian J Bush

Consortium
Publications

Bajaj JS, Lai JC, Tandon P, O'Leary JG, Wong F, Garcia-Tsao G, Vargas HE, Kamath PS, Biggins SW, Limon-Moro A, Shaw J, Mbachi C, Chew M, Deeb JG, Thacker LR, Reddy KR.
Clin Gastro Hep 2023

PMID:36328307
View Publication
Wong F, Reddy KR, Tandon P, Lai JC, Garcia-Tsao G, O'Leary JG, Biggins SW, Vagas HE, Thacker L, Kamath PS, Bajaj JS; NACSELD III Study Group. Am J Gastro 2024
- PMID: 39601412
- DOI: 10.14309/ajg.0000000000003251
Bajaj JS, Reddy KR, Tandon P, Lai JC, O'Leary JG, Wong F, Garcia-Tsao G, Vargas HE, Kamath PS, Biggins SW, Vutien P, Shaw J, Limon Miro AT, Bera C, McGinley JP, Sikaroodi M, Bush BJ, Thacker LR, Gillevet PM.Hepatology. 2025 Jul 9. doi: 10.1097/HEP.0000000000001462. Online ahead of print.PMID: 40632657
https://pubmed.ncbi.nlm.nih.gov/40632657/
Lai J, O'Leary JG, Tandon P, Wong F, Garcia-Tsao G, Kamath PS, Biggins SW, Vargas HE, Thacker LR, Bush BJ, Silvey S, Reddy KR, Bajaj JS.Clin Gastroenterol Hepatol. 2026 May 8:S1542-3565(26)00329-0. doi: 10.1016/j.cgh.2026.04.024. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/42107855/

Meeting Abstracts

Vasco Pontinha1, Rajender Reddy2, Puneeta Tandon3, Jennifer C. Lai4, Florence Wong5, Hugo E. Vargas6, Patrick S. Kamath7, PHILIP VUTIEN8, Guadalupe Garcia-Tsao11, Scott Biggins9, Jacqueline G. O'Leary10, BRIAN J BUSH1, Jasmohan S. Bajaj. DDW meeting 2026.
1. Jasmohan Bajaj Jennifer Lai2Puneeta Tandon3Jacqueline O'Leary4Florence Wong5Guadalupe Garcia-Tsao6Hugo Vargas7Philip Vutien8Scott Biggins9Kaitlyn Wethey10Tahira Shaikh11Stephanie Tsai12Jawaid Shaw13Andrew Fagan14Patrick Kamath15Leroy Thacker13K Rajender Reddy16, Liver meeting 2025, Abstract 0143
Jasmohan Bajaj K Rajender Reddy2Jennifer Lai3Jacqueline O'Leary4Puneeta Tandon5Florence Wong6Guadalupe Garcia-Tsao7Hugo Vargas8Patrick Kamath9Scott Biggins10Philip Vutien11Ana Limon-Moro12Jawaid Shaw13Masoumeh Sikaroodi14Brian Bush15Leroy Thacker15Patrick Gillevet14 Liver meeting 2025, Abstract 0237
Jennifer C. Lai, Puneeta Tandon, Jacqueline G O'Leary, Florence Wong, Guadalupe Garcia-Tsao, Patrick S Kamath, Scott W Biggins, Hugo E Vargas, Leroy R Thacker, Brian J Bush, K Rajender Reddy, Jasmohan S Bajaj
Oral Presentation DDW 2025
Jasmohan Bajaj1 Puneeta Tandon2 Jennifer Lai3 Jacqueline Oleary4 Guadalupe Garcia-Tsao5 Hugo Vargas6 Florence Wong7 Scott Biggins8 Patrick Kamath9 Philip Gunst10 Scott Hutton10 Brian Bush11 K Rajender Reddy12
AASLD Liver Meeting 2024
Jasmohan Bajaj1 Masoumeh Sikaroodi2 Marcela Peña Rodríguez3 Puneeta Tandon4 Jennifer Lai5 Jacqueline Oleary6 Guadalupe Garcia-Tsao7 Florence Wong8 Hugo Vargas9 Scott Biggins10 Patrick Kamath11 Brian Bush12 K Rajender Reddy13 Patrick Gillevet2
AASLD Liver Meeting 2024
Bajaj, Jasmohan S.1; Tandon, Puneeta2; Lai, Jennifer C.3; O'Leary, Jacqueline G.4; Wong, Florence5; Garcia-Tsao, Guadalupe6; Vargas, Hugo E.7; Biggins, Scott W.8; Kamath, Patrick S.9; Thacker, Leroy R.1; Reddy, Rajender10
Digestive Disease Week 2024
Jasmohan Bajaj1 , Puneeta Tandon2 , Jennifer Lai3 , Jacqueline O'leary4 , Guadalupe Garcia-Tsao5 , Hugo Vargas6 , Scott Biggins7 , Florence Wong8 , Patrick S. Kamath9 , Nicolas Lugon5 , Ana Limon-Miro2 , Jawaid Shaw1 , Brian Bush1 , K. Rajender Reddy10
EASL Congress 2024
Gowthami Kanagalingam1, Dan Park2, Bryan Badal3, Andrew Fagan2, K Rajender Rajender Reddy4, Jacqueline G. O'Leary5, Jennifer C. Lai6, Puneeta Tandon7, Florence Wong8, Patrick S. Kamath9, Guadalupe Garcia-Tsao10, Scott W. Biggins11, Hugo E. Vargas12, Chathur Acharya13 and Jasmohan S. Bajaj2.
Liver Meeting 2023
Jasmohan S Bajaj, Guadalupe Garcia-Tsao, Puneeta Tandon, Jennifer Lai, Jacqueline O'Leary, Hugo Vargas, Scott Biggins, Patrick S. Kamath, Florence Wong, Jawaid Shaw, Chimezie Mbachi, Jade Ikahihifo-Bender, Leroy Thacker, K Rajender Reddy.
EASL Congress 2023
Florence Wong1 , K. Rajender Reddy2, Puneeta Tandon3 , Jennifer Lai4 , Guadalupe Garcia-Tsao5 , Jacqueline O’Leary6 , Scott W Biggins7 , Hugo Vargas8 , Leroy Thacker9 Jasmohan S Bajaj10.
EASL Congress 2023
Dr. Jasmohan S. Bajaj1, Dr. Jennifer Cindy Lai, MD2, Dr. Puneeta Tandon, MD, FRCPC3, Dr. Jacqueline G. O'Leary, MD, MPH4, Dr. Guadalupe Garcia-Tsao, MD, FAASLD5, Dr. Florence Wong, MD, FAASLD6, Dr. Hugo E. Vargas7, Dr. Patrick S. Kamath, MD8, Dr. Scott W. Biggins9, Jade Ikahihifo-Bender10, Ana Limon-Moro3, Chimezie Mbachi11, Andrew Fagan12, Dr. Jawaid A. Shaw13 and Dr. K Rajender Reddy, MD, FAASLD14.
AASLD Liver Meeting 2022
Bajaj, Jasmohan S.1; Lai, Jennifer C.2; Tandon, Puneeta3; O'Leary, Jacqueline G.4; Garcia-Tsao, Guadalupe5; Wong, Florence6; Vargas, Hugo E.7; Kamath, Patrick S.7; Biggins, Scott W8; Shaw, Jawaid1; Limon-Miro, Ana Teresa3; Chew, Michael5; Mbachi, Chimezie5; Thacker, Leroy R1; Reddy, Rajender9
DDW 2022
Dr. Jasmohan S. Bajaj1, Dr. Jennifer C Lai, MD2, Dr. Puneeta Tandon, MD, FRCPC3, Dr. Florence Wong, MD, FAASLD4, Dr. Jacqueline G O'Leary, MD, MPH5, Dr. Guadalupe Garcia-Tsao, MD, FAASLD6, Dr. Hugo E. Vargas7, Dr. Scott W Biggins8, Dr. Patrick S. Kamath, MD9, Aimee Stonelake10, Dr. Michael Chew11, Andrew Fagan12, Sara Mcgeorge13, Megan Kelly14, Randi Wong15, Elizabeth Hernandez5, Tahira Shaikh16, Ms. Melissa Reyes17, James Kashima8, Dr. Leroy Thacker18, Dr. K Rajender Reddy, MD, FAASLD19 and NACSELD-3.
Liver Meeting 2021

Determine the prognosis of outpatients with compensated and decompensated cirrhosis followed prospectively.

Focus: Hospitalizations and ACLF development, Clinical Predictors of 1-year and 5-year outcomes, & translational analysis.

Jasmohan S Bajaj, MD

K Rajender Reddy, MD

Jacqueline G O’leary, MD

Florence Wong, MD

Patrick S Kamath

Yale University, New Haven, CT

University of Alberta, Edmonton, Canada

University of Washington, Seattle, WA

University of California, San Francisco, CA

Mayo Clinic, Phoenix, AZ

VCU Data Coordinating Center, Richmond, VA

Statisticians: Scott Silvey PhD, Leroy R Thacker PhD

Data Management: Brian J Bush

Consortium
Publications

Meeting Abstracts

NACSELD 3

NACSELD 2

NACSELD 1

Determine the prognosis of outpatients with compensated and decompensated cirrhosis followed prospectively.

Focus: Hospitalizations and ACLF development, Clinical Predictors of 1-year and 5-year outcomes, & translational analysis.

Jasmohan S Bajaj, MD

K Rajender Reddy, MD

Jacqueline G O’leary, MD

Florence Wong, MD

Patrick S Kamath

Yale University, New Haven, CT

University of Alberta, Edmonton, Canada

University of Washington, Seattle, WA

University of California, San Francisco, CA

Mayo Clinic, Phoenix, AZ

VCU Data Coordinating Center, Richmond, VA

Statisticians: Scott Silvey PhD, Leroy R Thacker PhD

Data Management: Brian J Bush

ConsortiumPublications

Role of Oral Health, Frailty, and Minimal Hepatic Encephalopathy in the Risk of Hospitalization: A Prospective Multi-Center Cohort of Outpatients With Cirrhosis

Sex differences in patient-reported outcomes and perception of ascites burden amongst outpatients with decompensated cirrhosis and ascites.: Sex Differences in Ascites Burden Perception

Salivary microbiome and serum metabolomics add to clinical biomarkers to predict 6-month hospitalizations in a multi-center cirrhosis outpatient cohort

Frailty increases hospitalization rates in an ambulatory cohort of patients with cirrhosis: The NACSELD3 prospective cohort

Meeting Abstracts

RESOURCE UTILIZATION IN A MULTI-CENTER OUTPATIENT CIRRHOSIS COHORT ACROSS PRACTICE TYPES DIFFERENTIALLY AFFECTS NEED FOR ACUTE CARE OVER TIME.

FRAILTY, COGNITIVE IMPAIRMENT AND COMORBID CONDITIONS ADD TO CIRRHOSIS SEVERITY IN PREDICTION OF 12-MONTH HOSPITALIZATIONS IN A MULTI-CENTER OUTPATIENT CIRRHOSIS COHORT

SALIVARY MICROBIOME AND SERUM METABOLOMICS ADD TO CLINICAL BIOMARKERS TO PREDICT 6-MONTH HOSPITALIZATIONS IN A MULTI-CENTER CIRRHOSIS OUTPATIENT COHORT

FRAILTY AND HOSPITALIZATION RATES IN AN AMBULATORY COHORT OF PATIENTS WITH CIRRHOSIS: FROM THE NORTH AMERICAN CONSORTIUM FOR THE STUDY OF END-STAGE LIVER DISEASES (NACSELD)

BLOOD METABOLOMICS PREDICT 6-MONTH HOSPITALIZATIONS IN A MULTICENTER PROSPECTIVE NORTH AMERICAN COHORT OF OUTPATIENTS WITH CIRRHOSIS

SALIVARY MICROBIOME IS INDEPENDENTLY ASSOCIATED WITH HOSPITALIZATIONS IN A MULTI-CENTER PROSPECTIVE COHORT OF OUTPATIENTS WITH CIRRHOSIS: NACSELD3 EXPERIENCE

Stroop Performance and Opioid Use Predict 3-Month Hospitalization in the Multi-Center Prospective Outpatient NACSELD-3 Cohort

Untargeted Serum Metabolomic Profiles Remain Stable Over Time in Large Multi-Center Cohort of >700 Outpatients with Cirrhosis

Determining Clinically Meaningful Difference In Baseline Encephalapp Stroop Values To Predict He-Related Outcomes With Multi-Center Validation

Prognostic Significance Of Individual Decompensating Events In Stable Decompensated Outpatients With Cirrhosis Using A Multi- Center Cohort

Gender Differences In The Patient-Reported Outcomes And Perception Of Ascites Burden Amongst Outpatients With Decompensated Cirrhosis And Ascites

Encephalapp Stroop But Not Animal Naming Test Or Mini-Mental Status Exam Associates With All-Cause And Hepatic Encephalopathy Admissions In A Multicenter Cirrhosis Cohort

Prior Periodonitis And Patient-Reported Outcomes Predict The Risk Of 3-Month Hospitalization In A Multi-Center Cirrhosis Cohort

New Functional Capacity In Cirrhosis Is Predicted By Additive Impact Of Covert Hepatic Encephalopathy And Frailty In A Multi-Center Outpatient Cohort

NACSELD 3

NACSELD 2

NACSELD 1

Consortium
Publications